What should officials do when three or more substitutes enter the game during a substitution opportunity?

When three or more substitutes enter the game during a substitution opportunity, the appropriate action is to grant the captain's request for a defensive match-up. This allows the team to match up defensively against the incoming substitutes, ensuring a fair and competitive game environment.

In basketball, allowing the captain to have a say in defensive match-ups fosters strategy and teamwork. This is particularly important because the introduction of multiple new players can alter the dynamics on the court. Understanding that a captain has the authority to request this match-up enhances team coordination and can significantly impact the game's flow.

The other options do not align with common procedures in officiating. Disallowing substitutions would be inappropriate, as substitutions are part of the game’s natural progression. Calling a time-out may not be necessary or logical in this context, as it does not cater to the teams' strategic needs at that moment. Conducting a player review does not apply here, as the scenario is straightforward concerning player substitutions and match-ups.